The rationale behind the therapy is based on further insight into the pathogenesis of OLP as an immune-mediated disease related to T-lymphocyte immunological dysfunction, and within the implicated cytokines, such as TNF-alpha, IFN-gamma, TNF-alpha, IL-6, and IL-8, which has paved the way for the utilization of immunosuppressant therapies. This evidence concerns the gene TNF and oral lichen planus.