Finally, a recent study highlighted the role of impaired glycosylation in the pathogenesis of X-linked immunodeficiency with magnesium defect, Epstein–Barr virus (EBV) infection, and neoplasia (XMEN) disease, caused by hemizygous LOF mutations in the magnesium transporter 1 (MAGT1) gene127,128. This evidence concerns the gene MAGT1 and X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia.