We observed that expression levels of proliferation-related genes, including PCNA (Pcna), Ki67 (Mki67), p35 (Cdk5r1), CDC2 (Cdk1), cyclin A2 (Ccna2), cyclin D1 (Ccnd1), and cyclin D2 (Ccnd2), were decreased in HF-fed Egr1-/- mice compared to those in HF-fed WT mice (Figure 4F). The gene discussed is CDK5R1; the disease is hydrops fetalis.