CYP11A1 and Familial prostate cancer: Here, we showed that ERRα, which exhibited an up-regulation pattern in metastatic CRPC and also xenograft model of CRPC, could function to promote the resistance to androgen-deprivation in prostate cancer cells and also enhance the intratumoral androgen biosynthesis via its transcriptional regulation of some key androgen biosynthetic enzyme genes, including CYP11A1 and AKR1C3.