IRS analysis revealed that higher GS lesions (GS ≥ 7) exhibited significantly higher AKR1C3 IRS scores as compared to lower GS lesions (GS ≤ 6) and BPH tissues (Figure S4F), suggesting that ERRα and AKR1C3 manifested a positive correlation in their immunoreactivity scores (Figure 4E). The gene discussed is ESRRA; the disease is benign prostatic hyperplasia.