qRT-PCR analysis of ERRα- or shERRα-transduced prostate cancer clones showed that the LNCaP-ERRα transduced clones expressed significant higher mRNA levels of three steroidogenic enzymes (CYP11A1, AKR1C3 and CYP17A1), whereas the LNCaP-shERRα transduced clones exhibited significant reduced levels of three steroidogenic enzymes (CYP11A1, AKR1C3 and HSD17B3) (Figures 4A and B). Here, AKR1C3 is linked to Familial prostate cancer.