In multiple myeloma cells, YY1 also regulates cell survival by forming complex with RelA and directly repress the promoter of a pro-apoptotic gene, Bcl2-interacting mediator of cell death (Bim)71, and promotes chemoresistance to cytotoxic chemotherapeutic drug bortezomib 72. This evidence concerns the gene BCL2L11 and plasma cell myeloma.