In some pancreatic cancers, YY1 could inhibit tumor proliferation, angiogenesis and metastasis by directly repressing tubulin polymerization-promoting protein (TPPP) and cyclin-dependent kinase inhibitor 3 (CDKN3) promoter activity 11, 141, 142, and high expression of YY1 is related with better prognosis 143. Here, YY1 is linked to familial pancreatic carcinoma.