The HIF-1 complex, in turn, activates genes promoting angiogenesis, such as VEGF, FGF2, and PDGFB. In addition, HIF-1α can activate genes involved in cell survival and metabolism, such as PGK, CA9, BNIP3, and GLUT1, all of which benefit tumor progression 30. This evidence concerns the gene VEGFA and neoplasm.