FBXW7 and cancer: FBXW7 is a tumor suppressor strongly suppressed the cancer cells proliferation, however the role of FBXW7 can be significantly inhibited by several mi-RNAs including miR-25, miR-92, miR-182, miR194, miR-223 and miR-503 in gastric, esophageal, colorectal, breast and cervical cancer cells 175-179.