AKT1 and cancer: Their key functions largely depend on their ubiquitination abilities on substrates involved in cancer hallmark pathways, including cell cycle, DNA damage, epithelial-mesenchymal transition (EMT) as well as multiple signaling pathways like AKT/PI3K, BMP, p53, NRF2, AMPK/mTOR, AKT, NF-κB and Hippo pathway 7, 11-21 all of which can contribute to tumor growth, proliferation, progression, metastasis and invasion.