Although only 60 genes showed overlap between Nrf2 and HIF1α in ChIP-seq (Fig. 6A), WikiPathway analysis (https://biit.cs.ut.ee/gprofiler/gost) revealed that both Nrf2 and HIF1α are the key regulators for the genes in metabolic and hepatocellular carcinoma (HCC) pathways (Fig. 6B). This evidence concerns the gene HIF1A and hepatocellular carcinoma.