CUB Domain-Containing Protein 1 (CDCP1) is a single span transmembrane receptor 3 that relays cancer promoting signals via other receptors such as EGFR 4, HER2 5 and β1 integrin 6,7, as well as mediators of metabolism such as acyl CoA-synthetase 8 and key intracellular signal transducers including Src 9-12, PKCδ 13, Akt 6,13 and FAK 6,14. The gene discussed is CDCP1; the disease is cancer.