However, IL-37 expression was negatively correlated with histologic grade (χ2 = 26.972, P < 0.01, r = -0.563), tumor size (χ2 = 18.378, P < 0.01, r = -0.465), lymph node metastasis (χ2 = 39.178, P < 0.01, r = -0.679), and vessel invasion (χ2 = 19.552, P < 0.01, r = -0.480) (Table 1). The gene discussed is IL37; the disease is metastatic malignant neoplasm in the lymph nodes.