CD47-high cells SW480 and HCT116 were more sensitive (IC50≈5μM) to ENOblock than CD47-low cells DLD1 and HCT8 (IC50≈40μM) (Figure 6A), suggesting that CRC cells with high expression of CD47 and ENO1 may be more sensitive to ENOblock. The gene discussed is CD47; the disease is colorectal carcinoma.