These results indicate that overexpression of TNFAIP8 induces the EMT process while reducing TNFAIP8 expression inhibits EMT development, providing evidence that TNFAIP8 regulates the EMT in ccRCC cells, thereby promoting migration and metastasis in ccRCC. This evidence concerns the gene TNFAIP8 and nonpapillary renal cell carcinoma.