Recent studies have shown that the expression level of TNFAIP8 is associated with tumor stage and lymph node metastasis (TNM) in esophageal squamous cell carcinoma 32, and similar phenomena have been observed in pancreatic cancer 33, gastric adenocarcinoma 34, breast cancer 35, and endometrial cancer 36. Here, TNFAIP8 is linked to familial pancreatic carcinoma.