For instances, lncRNA metastasis-associated lung adenocarcinoma transcript 1 (lncMALAT1) acts as a tumor-suppressive role in glioma by downregulating matrix metallopeptidase 2 (MMP2) and inactivating the ERK/MAPK signaling 21, upregulation of lncHOXA-AS3 in glioma fosters tumor progression and indicates poor prognosis 22, lncRNA colon cancer‐associated transcript 2 (lncCCAT2) is highly expressed in glioma and can promote cell growth and migration 23. The gene discussed is MMP2; the disease is glioma.