One of the reasons is that we have been encountering a logical plight for decades regarding our research strategies and approaches, as repeatedly pointed out by us before 47, 296, 720, 762: the results from the approaches we used, such as genetic engineering, can only tell us that certain manipulations or alterations, like concomitant overexpression of the c-myc and a k-ras mutant, and the ensuing cascades of molecular changes, can eventually cause neoplastic transformation or tumor formation. This evidence concerns the gene MYC and neoplasm.