To investigate the mechanism that leads to the downregulation of CHODL in CRC, we searched for CpG islands in the promoter of CHODL (http://cpgislands.usc.edu/), and the region from -873 to 1577 relative to the transcription start site of CHODL was analyzed (Figure 1D). The gene discussed is CHODL; the disease is colorectal carcinoma.