RETN and breast carcinoma: When we analyzed the clinical aspects of rs7408174 and rs3219175 RETN genotypic frequencies among breast cancer subtypes, we found that among patients with the luminal A subtype, those carrying the CT genotype at SNP rs7408174 were much more likely than TT genotype carriers to develop stage III/IV disease and pathological grade II and III disease (OR: 3.084; 95% CI: 1.146-8.299 and 3.983; 1.531-10.362, respectively) (Table 4).