In analyses that adjusted for confounders, study participants with the AG or the AG+AA genotype of the RETN rs3219175 polymorphism were around twice as likely to develop breast cancer as compared with those who were GG homozygous (AOR: 2.202; 95% CI: 1.701-2.243 and 1.869; 1.457-2.397, respectively; p<0.05 for both comparisons). The gene discussed is RETN; the disease is breast cancer.