For instance, single-nucleotide polymorphisms (rs734232) affecting the consensus-binding site for RUNX1, or Runx1 itself, are associated with susceptibility to rheumatoid arthritis and psoriasis (76–78), while Stat3 gene was identified as risk locus for Crohn's disease and MS (79, 80). The gene discussed is RUNX1; the disease is Crohn disease.