Several studies have outlined the molecular basis of such resistance, for instance, Yamada et al. (2017) reported terbinafine resistant strains (∼1%) collected from patients with tinea pedis or unguium, all of which were found to harbor missense mutations in the SQLE gene, leading to single amino acid substitutions at one of four positions (Leu393, Phe397, Phe415, and His440) of the SQLE enzyme. This evidence concerns the gene SQLE and tinea infection.