Furthermore, a SNP in the non-coding region of TNFAIP3 (rs2327832) is associated with lower C-peptide and higher HbA1c (hemoglobin A1c) levels, which indicates reduced beta-cell function and impaired glycemic control in children with recent onset of T1DM (84). Here, TNFAIP3 is linked to type 1 diabetes mellitus.