In summary, IFIH1 may play an important role in the pathogenesis of T1DM by regulating the innate immune response, especially the type 1 IFN signaling pathway; as the downregulation of IFIH1 may have a positive effect on preventing the onset of T1DM in the initial phase, it may become a useful strategy for preventing T1DM in the future. Here, IFIH1 is linked to type 1 diabetes mellitus.