KMO and schizophrenia: Elevated kynurenate levels have been observed in post-mortem schizophrenia brain tissue (46), while rats treated with kynurenine-3-monooxygenase inhibitors have reduced pre-pulse inhibition (reflecting the inability of schizophrenia patients to filter out extraneous stimuli), along with increased firing rate and burst firing activity of VTA dopaminergic neurons, indicating the dopamine hyperactivity associated with schizophrenia (47).