CXCR1 and congestive heart failure: Additionally, the lack of effect of CC inhibition on vastus lateralis HHb, despite improved central oxygen transport during exercise supports previous evidence that patients with CHF have a peripheral limitation to exercise (LeJemtel et al., 1986; Sullivan et al., 1989; Wilson et al., 1993; Coats et al., 1994; Esposito et al., 2010, 2011; Bhella et al., 2011).