PLN and familial dilated cardiomyopathy: A recent study in hiPSC-CM generated from a dilated cardiomyopathy (DCM) patient with PLN mutation showed an increase in the spontaneous beating rate, which could be reverted by genetic correction (Karakikes et al., 2015), and this suggested a link between T3-EC-induced PLN upregulation and the observed reduction in automaticity in our study.