Many small molecules are important triggers of liver fibrosis, such as tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), and transforming growth factor-beta (TGF-β), which possess effective pro-inflammatory or anti-inflammatory effects (Seki and Brenner, 2015; Kim et al., 2016; Al-Hashem et al., 2019; Xu et al., 2019). This evidence concerns the gene TNF and Hepatic fibrosis.