The effects of T. arjuna are associated also with reduction of RV hypertrophy and %MWT of pulmonary artery, with decrease lipid peroxidation and NOX1 protein expression in lung and with increase the SOD and CAT, also with decrease in BCL2/BAX ratio mRNA demonstrating antiapoptotic effect of the T. arjuna in pulmonary hypertensive rats. This evidence concerns the gene NOX1 and pulmonary arterial hypertension.