In the last decade, we characterized As-derived Wnt1 as crucial actor in As–DAn crosstalk involved in neuroprotection against several neurotoxic and inflammatory insults (Marchetti and Pluchino, 2013; Marchetti et al., 2013; Marchetti, 2018) and the regulation of neurogenesis and SVZ plasticity via crosstalk with inflammatory and oxidative stress signaling pathways during aging and MPTP-induced parkinsonism (Marchetti et al., 2020). The gene discussed is WNT1; the disease is Parkinson disease.