Furthermore, knockdown of USP32 attenuated the resistance of GC cells to cisplatin in CCK8 assays, whereas overexpression of SMAD2 partially rescued the defect of USP32 silenced GC cells in cisplatin resistance (Figure 6B), suggesting that USP32 may confer chemoresistance in GC. The gene discussed is SMAD2; the disease is gastric cancer.