Taken together, the findings indicate that reductions of cell migration and invasion abilities caused by icotinib plus BDMC is mediated by repressing MMP-2, MMP-9 and VEGF and upregulating of E-cadherin, JunD and HLJ1, this process is associated with oxidative stress activation and autophagy induction in the TKI-resistant NSCLC cells. Here, DNAJB4 is linked to non-small cell lung carcinoma.