We also found the decreases of HK1 and VDAC2 expressions in the TKI-resistant NSCLC cells treated with icofinib plus BDMC compared with untreated or single drug treated cells, revealing the convergent mechanisms that potentiate mitochondria-dependent apoptosis by targeting VDAC proteins. The gene discussed is VDAC2; the disease is non-small cell lung carcinoma.