The decrease of EGFR activity was paralleled by reductions of EGFR downstream proteins AKT and JNK phosphorylation levels and Sp-dependent proteins Her2, c-Myc and survivin expressions, which are in line with the notion that the hyperactivated AKT pathway and increased expressions of Her2, c-Myc and survivin are associated with resistance to EGFR-TKI in NSCLC 32,33. This evidence concerns the gene MAPK8 and non-small cell lung carcinoma.