NLRP12 and obesity due to melanocortin 4 receptor deficiency: And in the case of NLRP12 protecting the diversity of intestinal microbiota 6, thereby preventing obesity 7, it has also been reported that Nlrp12 KO mice display significantly decreased intestinal microbial diversity due to increased innate immunity, resulting from the lack of inhibition of the non-canonical NF-κB pathway.