NLRP12 and malignant colon neoplasm: For example, in colitis-driven colon cancer, Nlrp12 knock-out (KO) mice experience a higher frequency of death, weigh less, have a shorter colon length, and have more severe disease progression than wild type (WT) mice, all of which may occur through NLRP12's inhibition of the non- canonical NF-κB pathway 3,4.