The top ten canonical pathways are all immune—related functions, such as antigen presentation (p-value = 2.2e-10), PD-1, PD-L1 cancer immunotherapy pathway (p-value = 2.0e-7), and allograft rejection signaling(p-value = 3.2e-7), and OX40 signaling(p-value = 4.7e-7, S3 Table). The gene discussed is CD274; the disease is cancer.