LDHA and cancer: The involvement of high ALDH expression in resistance to several cytotoxic drugs, including cyclophosphamide and its analogues, doxorubicin, cisplatin, arabinofuranosyl cytidine, temozolomide and taxanes, is well documented.53 Targeting ALDH with a specific inhibitor could be a useful strategy for overcoming CSN6-mediated drug resistance issues in cancers.