Smoking is associated with increased risk of CRC.4 Moderate to high intake of alcohol was shown to increase CRC risk in a linear dose–response association.5 Several studies found smoking was associated with a higher risk of MSI-high,6–10 CIMP-high,8,10,11 BRAF-mutated (mut)8,10,11 and KRAS-wild-type (wt) CRC12,13 while others found no differential association by CRC subtypes.13–16 In one study, alcohol was found17 to be associated with increased risk of MSI-high compared to MSS CRC. This evidence concerns the gene BRAF and colorectal carcinoma.