P2RY2 and liver disorder: Supporting our findings, in a model of carcinogenesis-induction by DEN injection, it was recently described that in a P2YR2-/- genetic background, DEN induced a smaller number of tumors and favored an early proliferative response upon toxic administration, indicating that cellular proliferation in response to liver injury, dependent on P2Y2R, is relevant to the liver disease progression [8].