AIF1 and central nervous system cancer: For RDT with 5-ALA, ionized calcium-binding adapter molecule 1 (Iba1)-positive macrophages were observed at the surface and within the subcutaneous tumors after treatment with multidose ionizing irradiation in combination with 5-ALA as demonstrated by the red immunohistochemical staining observed in samples from a rat glioma subcutaneous model [10].