We detected, by Western blotting, the higher expression of DNMT1 and DNMT3b in PTPRG-negative K562 cells compared to PTPRG expressing LAMA-84 cells, while DNMT3a, considered as a tumor suppressor in hematological malignancies [27], followed an opposite trend of expression, being present only in LAMA-84 cells (Figure 4D). This evidence concerns the gene DNMT3B and hematologic disorder.