APC and chronic myelogenous leukemia, BCR-ABL1 positive: Of note, nuclear β-catenin is involved in intrinsic BCR-ABL1 kinase-independent TKI resistance in primary CML cells [39] and PTPRG co-precipitates with β-catenin in enterocytes derived from transgenic mice, featuring the loss of the wild-type Apc allele (ApcMin−/−).