It investigated the risk of HHF among T2DM patients initiating empagliflozin vs. sitagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4i) [60] demonstrating that empagliflozin decreased the risk of HHF-specific by 50% and the risk of HHF-broad by 49%, independently of the doses of empagliflozin daily (10 mg or 25mg) for patients with and without baseline cardiovascular disease. Here, DPP4 is linked to type 2 diabetes mellitus.