GLP1R and Hypoglycemia: IdegLira (Degludec + Liraglutide) [39] and iGlarLixi (Glargine 100 + Lixisenatide) [40], a titratable fixed-ratio combination of insulin (Degludec or Glargine) plus GLP1-RA (Liraglutide or Lixisenatide), was found to be able to reduce the risk of hypoglycemia unawareness or hypoglycemia-associated complications, such as acute CV events.