CD8A and head and neck cancer: In more recent studies, Maybruck and colleagues correlated the EV-mediated dysfunction of CD8+T cells, in head and neck cancer, with the presence of the immunoregulatory protein, galectin-1 [58], while in ovarian carcinoma, tumor EVs inhibit the proliferation of CD4+ and CD8+ T cells by delivering the metabolic checkpoint molecule arginase-1 [59].