PD-L1 expression on tumor cells, detected both on the membrane and in the cytoplasm of tumor cells, is correlated with poor prognosis in NSCLC patients [124] and Azuma et al. [123] showed that expression of high-aggregated PD-L1 on tumor cells is associated with EGFR gene mutations. The gene discussed is CD274; the disease is non-small cell lung carcinoma.