CD8A and neoplasm: In particular, TEVs can inhibit the differentiation of myeloid and lymphoid progenitors as well as of dendritic cells (DCs), promote the expansion of myeloid-derived suppressor cells (MDSCs), inhibit the functions of natural killer (NK) cells, induce the apoptosis of CD8+ T cells, promote the expansion of Treg and Breg cells and foster the polarization of macrophages in M2 like-tumor associated macrophages (TAMs) [3].