As well as NAFLD which shares similar pathogenetic pathways, particularly metabolic or immunological, with psoriasis, with co-occurence in up to 50% of the patients [26,27], there is increasing interest to comprehend whether PCSK9 has a positive or negative impact on the inflammation in chronic and autoimmune diseases [28,29]. The gene discussed is PCSK9; the disease is metabolic dysfunction-associated steatotic liver disease.