FLOT1 and Alzheimer disease: More specifically, flotillin-1 immunoreactivity has been shown to be higher in neurons bearing NFTs in the amygdala, hippocampus, and isocortex of AD patients compared with controls [36], and flotillin-1 was found to be co-localized with cathepsin-D, a lysosomal protease, indicating its contribution to lysosomal degradation [36].