There, CAP treatment in in vitro experiments with various osteosarcoma cell lines not only led to a reduction in cell proliferation and aktivation of apoptosis, but also to induction of transforming growth factor-beta 2 (TGF-β2), a potentially tumor suppressive factor in osteosarcoma and suppression of the angiogenic factor VEGFA (vascular endothelial growth factor A). This evidence concerns the gene TGFB2 and osteosarcoma.