MKI67 and neoplasm: This study demonstrated that although high T-bet expression is associated with adverse clinicopathologic characteristics, such as large tumor size, high histological grade, hormone receptor negativity, EGFR and p53 positivity, and a high Ki-67 index, T-bet+/high tumors have a more favorable outcome and longer disease-free survival time compared to T-bet−/low tumors [55].