CSF3R and central nervous system cancer: Since we are using the U-251 glioblastoma cell line as a model for astrocytes, the oncological effects of down-regulation of CSF3R, (Granulocyte-colony stimulating factor receptor), pave the way for repurposing these drugs towards cancer treatment as down-regulation of G-CSF/G-CSFR signalling is known to inhibit growth and metastasis of glioma cells [44].