CD274 and neoplasm: The hallmarks of this immunosuppressive environment are varied such as: Loss of antigen presentation machinery mediated by tumoral cells that makes them invisible to T cells, presence of enzymes, which deplete metabolites which play a key role in T cell function (as IDO or arginase), presence of immunosuppressive mediators (as TGFβ or IL-10) or cells (Treg) and the expression on the tumor membrane of membrane receptors, which induce T cell apoptosis, is one of the most known of the programmed death ligand 1 (PD-L1) [70].