In line with our earlier finding that nc886− cells are more proficient at G1-S transition than nc886+ cells, the expression of CDKN2A and CDKN2C was positively correlated with nc886 in the 108 ESCC patients (Figure 4C) and was also upregulated in 293T-U6:nc886 cells (Figure 4D). Here, CDKN2A is linked to esophageal squamous cell carcinoma.