AIM2 and neoplasm: Therefore, PRR-receptors such as Toll-like receptors (TLR), nucleotide-binding oligomerization domain-like receptors (NOD-like receptors), the stimulator of interferon genes (STING) pathway and inflammasomes, such as absent in melanoma 2 (AIM2), have been shown to play an important role in the intratumoral signaling and tumor growth inhibition and might thus have a marked effect on patient outcome [9,10,11].