Depletion of the BRCA1 protein has been reported in the neuronal cultures exposed to Aβ oligomers, in transgenic mice expressing human Aβ precursor protein (APP) and in brains of AD patients [69], while silencing of neuronal BRCA1 expression in murine dentate gyrus resulted in neuronal and synaptic plasticity impairments as well as in deficits of learning and memory [69]. Here, APP is linked to Alzheimer disease.