MAPT and Alzheimer disease: Pharmacological modulation of tau seems to be a promising treatment of AD also in the context of the findings from a cohort study, which reported lower amounts of paired helical filament tau neurofibrillary tangles among AD death cases with a history of cancer proximate to death compared to AD cases without cancer history, while both these two groups had comparable loads of amyloid-β plaques in brain tissues [52].