One intriguing, although at this point speculative hypothesis, could be that the increased risk EOAD among black individuals diagnosed with cancer at <45 years of age could be associated with the BRCA1 gene, whose pathogenic mutations are associated with BC and other cancers, and were shown to be more prevalent among black women diagnosed with BC at ≤50 years of age relative to the young white breast cancer patients [68]. The gene discussed is BRCA1; the disease is cancer.