In lower grade glioma, IDH-mutated glioma could be subcategorized into astrocytoma (Tumor protein p53 and X-linked helicase II-mutated, TP53/ATRX-mutated, telomerase reverse transcriptase promoter intact, hTERT promoter intact, 1p/19q intact) and oligodendroglioma (TP53/ATRX intact, hTERT promoter-mutated, 1p/19q co-deleted) [1]. The gene discussed is TP53; the disease is central nervous system cancer.