Typically, TP63 mutations have been reported in Rapp–Hodgkin (MIM 129400), ADULT (acro–dermato–ungual–lacrimal–tooth; MIM 103285), EEC (ectrodactyly–ectodermal dysplasia–cleft lip/palate; MIM 604292), Hay–Wells (MIM 106260), limb–mammary (MIM 603543), and split hand/foot malformation (MIM 605289) syndromes. The gene discussed is TP63; the disease is HIV-associated neurocognitive disorder.