To further explore the role of the Wnt-signaling pathway in lung cancer tumorigenesis, we performed a whole transcriptome analysis performing RNA-seq on 14 samples, including nine NSCLC samples, six of them with an inverse expression profile between ITF2 and DKK1, Patient 3 (Pat3), Patient 6 (Pat6), Patient 10 (Pat10), Patient 22 (Pat22), Patient 25 (Pat25), and Patient 26 (Pat26); and three with the same expression profile, Patient 8 (Pat8), Patient 16 (Pat16), and Patient 18 (Pat18) (Table S3). Here, TCF4 is linked to lung cancer.