DKK1 and lung cancer: However, the statistical significance of both genes in predicting overall survival was confirmed by analyzing an extended cohort of 1926 lung cancer patients using the Kaplan–Meier plotter online tool, revealing that those patients with high expression of ITF2 (Figure 4D) and low expression of DKK1 (Figure 4E) had a significantly better overall survival rate (p = 0.016 and p < 0.001, respectively).