In total 14 StVs were identified in the primary and PDX models for T-ALL samples; 4 unique fusions (STIL-TAL1, SPTAN1-ABL1), 7 retained introns (EIF4A, IRF8, KMT2A, NF1, SETD2), and 3 molecules with exon duplications (BCL11B and ZCCH7). Here, KMT2A is linked to acute lymphoblastic leukemia.