DYSF and neuromuscular disease caused by qualitative or quantitative defects of dysferlin: In general, dysferlin-deficient (dysf−/−) mice mimic human dysferlinopathies, show a comparable disease progression with late-onset and similar, though milder, histopathological features, including loss of muscle mass, lipid droplets within slow twitch myofibres, adipocyte replacement of myofibres and inflammation (Grounds et al., 2014; Hornsey et al., 2013; https://www.jain-foundation.org/scientific-resources/research-tools/mouse-models-dysferlin-deficiency).