TRIM32 KO muscles also show a decrease in the glycolytic proteins GAPDH and PyK (Mokhonova et al., 2015), just as we observe a reduction in Ald and Pglym levels in tn-/- muscles, suggesting that TRIM32-mediated regulation of glycolysis may be a general mechanism that underlies some muscular dystrophies. The gene discussed is GAPDH; the disease is muscular dystrophy.